Tests Available

(Please note: we do not supply kits - we do assays on supplied samples.)

Larger batches and multiple test requests will be discounted: please contact us with your requirements and we will be pleased to quote.

Screening Tests:

1. Prothrombin Time (PT)
2. activated Partial Thromboplastin Time (aPTT)
3. Thrombin Clotting Time (TCT)
4. Kaolin Clotting Time (KCT)

Assessment of the Fibrinolytic Pathway:

1. Alpha-2-antiplasmin - functional assay
2. Euglobulin Lysis Time
3. Fibrinogen/fibrin degradation products (FDP)
4. Plasmin alpha-2-antiplasmin complex (PAP)
5. Plasminogen Activator Inhibitor - antigen (PAI-1)
6. Plasminogen Activator Inhibitor - functional (PAI-1)
7. Plasminogen - antigen
8. Plasminogen - functional assay
9. Thrombin Activatable Fibrinolytic Inhibitor (TAFI)
10. Tissue Plasminogen Activator (t-PA) - total antigen
11. Tissue Plasminogen Activator (t-PA) - functional assay

Thrombosis Screening Tests:

1. Activated Protein C Resistance assay (APCR)
2. Anti-thrombin - antigen
3. Anti-thrombin - functional assay
4. Factor XI antigen
5. Heparin Cofactor II - functional (chromogenic)
6. Heparin Cofactor II - antigen
7. Heparin-induced antibody assay (HIT):
   • PF4 Binding assay
   • Serotonin Release assay
8. Homocysteine
9. Lipoprotein (a)
10. Protein C - antigen
11. Protein C - functional assay (Clotting)
12. Protein C - functional assay (chromogenic)
13. Protein S - antigen (total and/or free antigen)
14. Protein S - functional assay (Clotting)
15. Reptilase
16. Tissue Factor Pathway Inhibitor (TFPI)

Markers of Thrombin Generation:

1. Thrombin-antithrombin Complex (TAT)
2. Prothrombin fragment 1.2 (F1.2)
3. Activated Factor VII (VIIa)
4. D-Dimer (Quantitative and Semi-Quantitative)
5. Soluble Fibrin Monomer
6. Human Tissue Factor Ag
7. Endogenous thrombin potential

Markers of Platelet Activation:

1. Beta-Thromboglobulin (BTG)
2. Platelet Factor 4 (PF4)
3. P-Selectin

Measurement of thromboxane B2 suppression (Aspirin resistance)

1. 11-dehydro Thromboxane B2 (Urine)
2. Serum Thromboxane B2 assay.

Markers of Endothelial Activation:

1. sE-Selectin
2. Endothelin 1

Monitoring Anticoagulant Therapy:

1. Heparin anti-IIa assay
2. Heparin anti-Xa assay (LMWH, UFH, Fondaparinux)
3. Hirudin assay
4. Ecarin Clotting Time
5. Anti-Xa Heparin Assays for establishing an aPTT therapeutic range for Unfractionated Heparin (UFH).

Antiphospholipid Antibody Evaluation:

1. Anticardiolipin assay - specific measurement - IgG - IgM - IgA
2. Anti-phosphotidylserine
3. Anti-beta-2-glycoprotein
4. Clotting assays for Lupus Anticoagulant:
   - Dilute Russell viper venom time (DRVV)
   - Lupus sensitive aPTT
   - Dilute prothrombin time
   - Kaolin Clotting time
5. Confirmation Tests:
   - Hexagonal phospholipid
   - RVV Confirmation

Coagulation Protein Analysis:

1. Coagulant Assays - Factor II to XII Functional
2. Coagulant Assays - Factor II to XII Antigen
3. Factor VIII (Chromogenic)
4. Factor Inhibitor (FII to XII)
5. Factor VIII Inhibitor assay (Bethesda)
6. Factor XIII Assay - Quantitative (Chromogenic)
7. Fibrinogen - Clauss functional Assay
8. Fibrinogen antigen
9. Prekallikrein Assay (Chromogenic)
10. von Willebrand Factor antigen assay (vWF:ag)
11. von Willebrand Ristocetin CoFactor
12. Tissue Factor Acitivty

DNA Analysis:

1. Factor V Leiden R506Q mutation
2. Prothrombin 20210 AG genotype
3. Methyl Tetrahydrofolate Reductase (MTHFR) Mutation
4. Cytochrome P 450 CYP2C9 *2 & CYP2C9 *3
5. VKORC1 (vitamin K epoxide reductase complex, subunit 1)

Miscellaneous:

1. Adiponectin
2. Procalcitonin

Cytokines

1. IL-1 beta
2. IL-1 beta High Sensitivity
3. sIL-2R
4. IL-6
5. IL-1ra
6. IFN-gamma
7. MMP-3
8. MMP-9
9. s-ICAM-1
10. s-VCAM-1
11. TNF-alpha
12. TNF-alpha High Sensitivity
13. TGF-alpha
14. TGF-beta
15. TNF sTNF R1
16. TNF sTNF R2

Animal Studies:

1. Rabbit: Fibrinogen Antigen Assay, FDP Antigen Assay
2. Rabbit & Pig: Thrombin-Antithrombin (TAT)
3. Pig: D-Dimer, Tissue Plasminogen Activator Antigen (t-PA), IL-6, CRP, TNF-α
4. Canine: Factor Assays, Antithrombin, vWF antigen
5. Anti-Xa & Anti-IIa assay for all animals

Note that most functional assays can be applied to animal studies.