Tests By Group

(Please note: we do not supply kits - we do assays on supplied samples.)

Larger batches and multiple test requests will be discounted: please contact us with your requirements and we will be pleased to quote.

Markers of Thrombin Generation:

• Thrombin-antithrombin Complex (TAT)
• Prothrombin fragment 1.2 (F1.2)
• Activated Factor VII (VIIa)
• D-Dimer (Quantitative and Semi-Quantitative)
• Soluble Fibrin Monomer

Markers of Platelet Activation:

• Beta-Thromboglobulin (BTG) 
• Platelet Factor 4 (PF4) 
• P-Selectin 
• 11-dehydro Thromboxane B2 (urine)

Markers of Endothelial Activation:

• sE-Selectin

Screening Tests:

• Prothrombin Time
• aPTT (activated Partial Thromboplastin Time)
• Thrombin Clotting Time (TCT)

Assessment of the Fibrinolytic Pathway:

• Alpha-2-antiplasmin - functional assay
• Euglobulin Lysis Time
• Fibrinogen/fibrin degradation products (FDP)
• Plasmin alpha-2-antiplasmin complex (PAP)
• Plasminogen Activator Inhibitor - antigen (PAI-1)
• Plasminogen Activator Inhibitor - functional assay (PAI-1)
• Plasminogen - antigen
• Plasminogen - functional assay
• Thrombin Activatable Fibrinolytic Inhibitor (TAFI)
• Tissue Plasminogen Activator (t-PA) - total antigen
• Tissue Plasminogen Activator (t-PA) - functional assay

Monitoring Anticoagulant Therapy:

• Heparin anti-IIa assay
• Heparin anti-Xa assay (LMWH or unfractionated)
• Hirudin assay
• Ecarin Clotting Time
• Xa Heparin Assays for establishing an aPTT therapeutic renge for Unfractionated Heparin (UFH).

Thrombosis Screening Tests:

• Activated Protein C Resistance assay (APCR)
• Anti-thrombin - antigen
• Anti-thrombin - functional assay
• Factor XI antigen
• Heparin Cofactor II - functional (chromogenic)
• Heparin Cofactor II - antigen
• Heparin-induced antibody assay (HIT):
  • PF4 Binding assay 
  • Serotonin Release assay
• Homocysteine
• Lipoprotein (a)
• Protein C - antigen
• Protein C - functional assay
• Protein C - functional assay (chromogenic)
• Protein S - antigen (total and/or free antigen) 
• Protein S - functional assay
• Reptilase
• Tissue Factor Pathway Inhibitor (TFPI) 

Antiphospholipid Antibody Evaluation:

• Anticardiolipin assay - specific measurement
- IgG - IgM - IgA
• Anti-phosphotidylserine
• Beta-2-glycoprotein
• Clotting assays for Lupus Anticoagulant:
  - Dilute Russell viper venom time (DRVV)
  - Lupus sensitive aPTT
  - Dilute prothrombin time
  - Kaolin Clotting time
• Confirmation Tests:
- Hexagonal phospholipid - RVV Confirmation

Coagulation Protein Analysis:

• Coagulant Assays - Factor II to XII
• Factor VII antigen
• Factor VIII antigen
• Factor VIII (Chromogenic)
• Factor VIII Inhibitor
• Factor VIII Inhibitor assay (Bethesda)
• Factor XI Antigen
• Factor XIII Assay - Quantitative (Chromogenic)
• Fibrinogen - Claus functional Assay
• Fibrinogen antigen
• Prekallikrein Assay (Chromogenic)
• von Willebrand Factor antigen assay (vWF:ag)
• von Willebrand Factor antigen (monoclonal antibody to the functional site)
• von Willebrand Ristocetin CoFactor

DNA Analysis:

• Factor V Leiden R506Q mutation
• Prothrombin 20210 AG genotype
• Methyl Tetrahydrofolate Reductase (MTHFR)
• Tissue Factor Pathway Inhibitor (TFPI) Ê536C->T Transition
• PAI-1 4G/5G Polymorphism

Miscellaneous:

• Adiponectin
• Procalcitonin

Cytokines:

• IL-1 beta
• sIL-2R
• IL-6
• MMP-3
• MMP-9
• s-ICAM-1
• s-VCAM-1
• TNF-alpha

Animal Studies:

• Rabbit: Fibrinogen Antigen Assay, von Willebrand Antigen Assay
• Rabbit & Pig: Thrombin-Antithrombin (TAT)
• Pig: D-Dimer, Tissue Plasminogen Activator Antigen (t-PA), IL-6, CRP, TNF-α
• Canine: Factor Assays, Antithrombin, vWF antigen

Note that most functional assays can be applied to animal studies.